Prevention and mitigation of misuse of synthetic biology for bioterrorism purposes

Open

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Expected Outcome:
Project results are expected to contribute to all of the following expected outcomes:

• Increased understanding of European policy makers, research community, biotech companies, and relevant security practitioners of the threat of bioterrorism and of synthetic biology, including a thorough lawful analysis of what needs to be monitored in this context, what needs to be regulated and how;
• Awareness raised within the related scientific community how research in synthetic biology can be used for malicious purposes. Scope:
The rising threat of bioterrorism is driven by recent scientific advancements, notably by growing accessibility of synthetic biology, genetic engineering, related commercial services and public databases, which in turn enhance their obtainability to non-state actors and individuals with malicious intentions. The proliferation of do-it-yourself biohacking and community laboratories, including gene editing and sequencing technology, dropping costs of equipment and increased simplicity of use may inadvertently facilitate knowledge and skills dissemination about biological threats and open new pathways for bioterrorism. Challenges in detection, particularly the lengthy incubation periods of biological agents, underscore the urgent need for improved identification technologies to allow for timely intervention and reduce potential mass casualties, considering both characterization through advanced tools by expert labs and simple deployable methods. Given that properly weaponized biological agents can be more lethal than nuclear weapons, their cross-border implications warrant focused attention. Recent incidents involving biotoxins across various European countries illustrate the feasibility of biological attacks. The increasing weaponisation of drones highlights an alarming trend that could extend to biological agents, further complicating threat landscapes. The potential economic and social consequences of biological attacks necessitate robust prevention and preparedness measures to mitigate overwhelming impacts on healthcare systems and society at large.
Proposals are expected to address, in a lawful manner, the emerging threats of bioterrorism in Europe, particularly in the context of synthetic biology. Recognising bioterrorism as a low-probability but high-impact event, consortia should review current and future risks, flag areas requiring reinforced monitoring, as well as identify missing regulatory frameworks necessary for ensuring public security and safety. Furthermore, proposals should bring together diverse consortia to enhance our understanding, prevention, preparedness, and response to bioterrorism and create a comprehensive approach to this pressing issue.
Coordination among the successful proposals from this topic should be envisaged to avoid duplication and to exploit complementarities as well as opportunities for increased impact. In this topic the integration of the gender dimension (sex and gender analysis) in research and innovation content should be addressed only if relevant in relation to the objectives of the research effort.
Proposals funded under this topic are expected to provide ideas on how they would engage with the Europol Innovation Lab during the lifetime of the project. Similarly, if the proposals concern drug-related issues, they are expected to engage with the EU Drugs Agency during the lifetime of the project, including validating the outcomes.
Finally, proposals are expected to address all applicable considerations expressed in the Introduction of the Fighting Crime and Terrorism Destination.
Technology Readiness Level - Technology readiness level expected from completed projects
Activities are expected to achieve TRL 4-5 by the end of the project – see General Annex B.

Status

Open

Deadline

5 November 2026 (time not stated)

Opens

6 May 2026

Published

12 December 2025

Total budget

€3,000,000

Grant range

€3,000,000 – €3,000,000

Country

European Union (EU-wide)

Programme

Horizon Europe (HORIZON)

Funder

European Commission

Official page

Open at the source portal

What applying involves

13 steps, all of them taken from this call's own documents.

Understand the call

• Read the call on the source portal and download its documents
• Write the proposal against the award criteria and thresholds standard for this programme

  are described in Annex D of the Work Programme General Annexes — conditions §5a

• Check the grant's legal and financial set-up standard for this programme

  The granting authority may, up to 4 years after the end of the action, object to a transfer of ownership or to the exclusive licensing of results, as set out in the specific provision of Annex — conditions §6

• Check the amount you plan to request against the call's range

Check you are eligible

• Confirm your technology readiness level against the range the call states
• Check every partner is established in an eligible country standard for this programme

  described in Annex B of the Work Programme General Annexes. A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects. See the information in the Horizon Europe Programme Guide — conditions §2

• Meet the call's other eligibility conditions

  If projects use satellite-based earth observation, positioning, navigation and/or related timing data and services, beneficiaries must make use of Copernicus and/or Galileo/EGNOS (other data and services may additionally be used). described in Annex B of the Work Programme General Annexes — conditions §3

• Be able to show financial and operational capacity standard for this programme

  described in Annex C of the Work Programme General Annexes — conditions §4

• Check the conditions for financial support to third parties

Prepare the documents

• Prepare Part B of the Application Form standard for this programme

  Proposal page limits and layout: described in Part B of the Application Form available in the Submission System. — conditions

• Complete the detailed budget table standard for this programme

Submit

• Check the submission and evaluation process standard for this programme

  are described in Annex F of the Work Programme General Annexes and the Online Manual — conditions §5b

• Submit before the closing date shown above

  The source states the closing day but no closing time — check the portal before the last day. — calls.deadline

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